Standard suppository molds offer challenges to compounders, because they are time consuming both to use and to clean. Insert the suppository into the rectum, narrow end first. The sphincter is the muscular opening of the rectum. Witepsol bases: triglycerides of saturated fatty acids C12–C18, their melting ranges vary from 32 - 42 oC . 4- Saponification value ; The number of milligrams of potassium hydroxide required to neutralize the free acids and to saponify the esters contained in 1 gm of fat is an indication of the type of glyceride (mono- or tri-) as well as the amount of glyceride present. 21 Specifications of suppository bases The six general classes of suppository bases identified by the USP are described here. water/base partition coefficient. Oily bases or oleoginous bases 1.1. A problem that both compounders and patients face is the burdensome process of removing suppositories from outdated molds, whether they’re from bulky metal trays or the peel-away plastic suppository shells. [Article in Italian] These are made with best quality material and have sodium stearate as a component. Gently but firmly, push the suppository past the sphincter. Suppository bases. Suppository bases may be classified according to their composition and physical properties: 1- Oleaginous (fatty) bases 2- Water soluble or miscible bases 37 3- Miscellaneous Bases Specifications of suppository bases 1- Origin and chemical composition The source of origin (i.e. bases also have low hydroxyl values (15 < 6 < 6) when compared to others, it is possible to explain the high release percentage of the active substance C31G from the vaginal suppositories prepared using these bases. 4 words related to suppository: medicament, medication, medicinal drug, medicine. The influence of suppository bases upon the rectal absorption of acetylsalicylic acid. Antonyms for Suppository bases. PEG bases. Types of suppository bases by Hadeer Zedan 1. A suppository is a pill or medication that is inserted through the rectal area of the body. They are chemically stable, nonirritating, miscible with water and mucous secretions, and can be formulated, either by molding or compression, in a wide range of hardness and melting point. Describe the proper formulation, packaging, and administration of suppository bases. Fat-type suppository bases can be produced from a variety of vegetable oils, such as coconut or palm kernel, which are modified by esterification, hydrogenation, and fractionation to obtain products of varying composition and melting temperatures (e.g., Hydrogenated Vegetable Oil and Hard Fat).These products can be so designed as to reduce rancidity. We offer a wide range of suppository bases. It is contains the drugs which are used in treatment of the infections of female genitourinary tract and meant for contraception. Home Suppository Bases. 2.3. It is contains the combination of polyethylene glycol of different molecular weights as suppository bases. It's a small, round or cone-shaped object that you put in your body, often into your bottom. selection of suppository bases depends on. Wecobee bases: triglycerides derived from coconutoil. Identify the best product for your purpose and ask the related technical sheet to our team which will be pleased to help you. Important characteristics for suppositories include (1) hardness (for proper handling and delivery), (2) shape (for comfortable insertion and retention), (3) solubilization of drug in suppository matrix, and (4) rapid melting after application. Page 7 8. 1973 Feb;112(2):116-33. Search for more papers by this author. 1.2 Relationship between dossier specifications and the Pharmacopoeia Examples of Macrogol bases: I II III IV Macrogol 400 Macrogol 1000 Macrogol 1540 Macrogol 4000 Macrogol 6000 Water - - - 33 47 20 - - 33 - 47 20 20 - 33 - 47 - - 75 - 25 - - By choosing a suitable combination a suppository base with the desired characteristics can be prepared. Determine the density factor of a drug in polyethylene glycol suppositories. Solubility: Witepsol®H15 is readily soluble in diethylether, toluene and … 15 -25oC and melts at body temp (for oil based suppositories) • Amorphous, smooth, non-irritating vehicle • Medicinally inert without side effects Types: Oleaginous (fatty/oily) bases (lipophilic) Theobroma Oil (cocoa butter) & synthetic triglyceride mixtures o Water soluble bases (hydrophilic) What are synonyms for Suppository bases? A suppository base must remain solid at room temp. 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